Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24693030 | 1.00 | NR1H2 (0.40) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL19864002 | 0.86 | NR1H2 (0.49) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL12240672 | 0.83 | CHRNB2 (0.44) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL4744431 | 0.82 | CHRNB2 (0.50) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL25349088 | 0.81 | HSD11B1 (0.47) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL25349548 | 0.81 | HSD11B1 (0.47) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL1711297 | 0.80 | HSD11B1 (0.39) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL24692519 | 0.79 | NR1H2 (0.39) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL19583627 | 0.77 | CHRM2 (0.47) | NR1H2HSD11B1CHRM2CHRM1CHRM3 | |
| SCHEMBL31208799 | 0.77 | HSD11B1 (0.45) | NR1H2HSD11B1CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220387411-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | VULCAN BIO CORPORATION | 2022-12-08 | — | — | US | disclosed |
| US-20220387411-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | VULCAN BIO CORPORATION | 2022-12-08 | — | — | US | disclosed |
| EP-4034557-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | Frontier Medicines Corporation (US) | 2022-08-03 | — | — | EP | disclosed |
| WO-2021061858-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | FRONTIER MEDICINES CORPORATION (US) | 2021-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220387411-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | ATG7, BECN1, SQSTM1 | NR1H2 1199/4885HSD11B1 3821/4885CHRM2 4756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.