Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987524 | 0.93 | DRD2 (0.55) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL2319168 | 0.84 | DRD3 (0.67) | DRD2DRD4DRD3NTRK1MAPT | |
| SCHEMBL2318622 | 0.80 | DRD2 (0.51) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL2315158 | 0.78 | DRD3 (0.77) | DRD2DRD4DRD3NTRK1MAPT | |
| SCHEMBL29462329 | 0.78 | DRD3 (0.77) | DRD2DRD4DRD3NTRK1MAPT | |
| SCHEMBL2316307 | 0.74 | DRD2 (0.55) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL12208577 | 0.73 | ENPP2 (0.62) | DRD2DRD4DRD3KCNH2ALDH1A1 | |
| SCHEMBL30080681 | 0.69 | ALDH1A1 (0.45) | DRD2DRD4DRD3ALDH1A1KMT2A | |
| SCHEMBL2320805 | 0.68 | MAPT (0.63) | DRD2DRD4DRD3NTRK1MAPT | |
| SCHEMBL30080723 | 0.68 | MAPT (0.63) | DRD2DRD4DRD3NTRK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2354136-B1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-02-24 | — | — | EP | disclosed |
| US-9227944-B2 | Dopamine D3 receptor ligands and preparation and medical uses of the same | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY SCIENCE P.L.A. CHINA (CN) | 2016-01-05 | — | — | US | disclosed |
| US-20140329831-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A. CHINA (CN) | 2014-11-06 | — | — | US | disclosed |
| US-8829001-B2 | Dopamine D3 receptor ligands and preparation and medical uses of the same | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2014-09-09 | — | — | US | disclosed |
| US-20110319423-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A (CN) | 2011-12-29 | — | — | US | disclosed |
| EP-2354136-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS, THE PREPARATION AND USE THEREOF | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China (CN) | 2011-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319423-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | DRD3, DRD2, SLC6A3 | DRD2 2/4885DRD4 6/4885DRD3 1/4885 |
| US-20140329831-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | DRD3, DRD2, SLC6A3 | DRD2 2/4885DRD4 6/4885DRD3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.