Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2306725 | 0.90 | DGAT1 (0.48) | DGAT1CSF1RCSGALNACT1LCKNPC1 | |
| SCHEMBL2308884 | 0.86 | DGAT1 (0.60) | DGAT1CSGALNACT1LCK | |
| SCHEMBL2314966 | 0.86 | DGAT1 (0.60) | DGAT1CSGALNACT1LCK | |
| SCHEMBL2308048 | 0.86 | DGAT1 (0.60) | DGAT1CSGALNACT1LCK | |
| Bicarbonate SCHEMBL2307217 | 0.85 | KMT2A (0.52) | DGAT1CSF1RCSGALNACT1LCKNPC1 | |
| Bicarbonate SCHEMBL2311087 | 0.85 | CASP3 (0.54) | DGAT1CSF1RCSGALNACT1LCKNPC1 | |
| Bicarbonate SCHEMBL2307044 | 0.85 | CSF1R (0.44) | DGAT1CSF1RCSGALNACT1CCNA2CDK2 | |
| Bicarbonate SCHEMBL2307791 | 0.85 | DGAT1 (0.61) | DGAT1CSGALNACT1NPC1ALDH1A1RAB9A | |
| Bicarbonate SCHEMBL2311617 | 0.85 | DGAT1 (0.51) | DGAT1CSF1RCSGALNACT1NPC1ALDH1A1 | |
| Bicarbonate SCHEMBL2309547 | 0.84 | NPC1 (0.49) | NPC1ALDH1A1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | claimed |