Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23005772 | 0.84 | HSD17B10 (0.52) | ALOX15HSD17B10CYP3A4MAPTGAA | |
| SCHEMBL13008247 | 0.82 | ALOX15 (0.50) | ALOX15HSD17B10CYP3A4MAPTGAA | |
| SCHEMBL22905073 | 0.81 | TDP1 (0.42) | ALOX15CYP3A4MAPTGAAKDM4E | |
| SCHEMBL5595306 | 0.77 | LCK (0.55) | ALOX15HSD17B10CYP3A4MAPTGAA | |
| SCHEMBL23592021 | 0.76 | TSHR (0.50) | ALOX15HSD17B10CYP3A4MAPTKDM4E | |
| SCHEMBL24371583 | 0.75 | HSD17B10 (0.43) | ALOX15HSD17B10CYP3A4MAPTGAA | |
| SCHEMBL9790445 | 0.75 | HSD17B10 (0.43) | ALOX15HSD17B10CYP3A4MAPTGAA | |
| SCHEMBL766129 | 0.74 | HSD17B10 (0.52) | ALOX15HSD17B10CYP3A4MAPTGAA | |
| SCHEMBL29412590 | 0.74 | HSD17B10 (0.52) | ALOX15HSD17B10CYP3A4MAPTGAA | |
| SCHEMBL180385 | 0.73 | KDM4E (0.64) | ALOX15HSD17B10CYP3A4MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021061643-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-04-01 | — | — | WO | disclosed |