Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694581 | 0.81 | CCNA2 (0.47) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL8698915 | 0.78 | KDM4E (0.47) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL13536655 | 0.74 | HPGD (0.49) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL2315038 | 0.73 | CCNA2 (0.47) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL2315805 | 0.73 | NPC1 (0.45) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL2315072 | 0.72 | CCNA2 (0.46) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL3185793 | 0.70 | DRD4 (0.47) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL14264449 | 0.67 | FBP1 (0.47) | NPC1RAB9ADUSP3CCNA2CDK2 | |
| SCHEMBL257436 | 0.65 | RORB (0.66) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL13638641 | 0.65 | MEN1 (0.51) | NPC1RAB9ACCNA2CDK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349484-A2 | HETEROARYL DERIVATIVES AS DGAT1 INHIBITORS | Novartis AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010007046-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |