Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25493754 | 0.92 | L3MBTL1 (0.52) | L3MBTL1ALDH1A1PKMHCRTR1HCRTR2 | |
| SCHEMBL15693685 | 0.85 | L3MBTL1 (0.59) | L3MBTL1ALDH1A1NPC1PKMPKLR | |
| SCHEMBL12623925 | 0.83 | L3MBTL1 (0.67) | L3MBTL1ALDH1A1NPC1PKMPKLR | |
| SCHEMBL12621923 | 0.83 | L3MBTL1 (0.78) | L3MBTL1ALDH1A1NPC1PKMPKLR | |
| SCHEMBL23160004 | 0.82 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1HCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL18133264 | 0.82 | L3MBTL1 (0.66) | L3MBTL1ALDH1A1NPC1PKMPKLR | |
| SCHEMBL12623952 | 0.82 | L3MBTL1 (0.63) | L3MBTL1ALDH1A1NPC1PKMPKLR | |
| SCHEMBL12626117 | 0.81 | L3MBTL1 (0.50) | L3MBTL1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL12623987 | 0.81 | L3MBTL1 (0.65) | L3MBTL1ALDH1A1NPC1PKMPKLR | |
| SCHEMBL13353152 | 0.81 | L3MBTL1 (0.65) | L3MBTL1ALDH1A1NPC1PKMPKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11661580-B2 | Method of inhibiting tau phosphorylation | CASSAVA SCIENCES, INC. (US) | 2023-05-30 | — | — | US | disclosed |
| US-20210095248-A1 | METHOD OF INHIBITING TAU PHOSPHORYLATION | PAIN THERAPEUTICS, INC. | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210095248-A1 | METHOD OF INHIBITING TAU PHOSPHORYLATION | FLNA, FLNB, MAPT | L3MBTL1 1789/4885ALDH1A1 4388/4885NPC1 2309/4885 |
| US-11661580-B2 | Method of inhibiting tau phosphorylation | FLNA, FLNB, MAPT | L3MBTL1 1789/4885ALDH1A1 4388/4885NPC1 2309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.