Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936216 | 0.92 | OPRM1 (0.58) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL22387506 | 0.86 | SLC6A2 (0.51) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL2814615 | 0.85 | AGER (0.67) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL25073932 | 0.85 | AGER (0.60) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL20857048 | 0.82 | OPRM1 (0.56) | AGEROPRM1CHRM2CHRM3LMNA | |
| SCHEMBL17314167 | 0.81 | SLC18A3 (0.57) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL23144528 | 0.81 | SLC18A3 (0.54) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL17314168 | 0.81 | SLC18A3 (0.57) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL17314169 | 0.81 | SLC18A3 (0.57) | AGERNPC1ALDH1A1RAB9APAX8 | |
| SCHEMBL21865386 | 0.79 | TACR1 (0.47) | AGERNPC1ALDH1A1RAB9APAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220387411-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | VULCAN BIO CORPORATION | 2022-12-08 | — | — | US | disclosed |
| US-20220387411-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | VULCAN BIO CORPORATION | 2022-12-08 | — | — | US | disclosed |
| CN-115151561-A | Targeted autophagy conjugates and methods | 前沿药品公司 | 2022-10-04 | — | — | CN | disclosed |
| EP-4034557-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | Frontier Medicines Corporation (US) | 2022-08-03 | — | — | EP | disclosed |
| WO-2021061858-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | FRONTIER MEDICINES CORPORATION (US) | 2021-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220387411-A1 | TARGETED AUTOPHAGY CONJUGATES AND METHODS | ATG7, BECN1, SQSTM1 | AGER 1427/4885NPC1 48/4885ALDH1A1 3444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.