Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 9/20 | 0.51 |
| ▸ | GABRD | O14764 | 9/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 9/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 9/20 | 0.51 |
| ▸ | GABRE | P78334 | 9/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 9/20 | 0.51 |
| ▸ | GABRG1 | Q8N1C3 | 9/20 | 0.51 |
| ▸ | GABRG3 | Q99928 | 9/20 | 0.51 |
| ▸ | GABRQ | Q9UN88 | 9/20 | 0.51 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459368 | 0.87 | GABRP (0.50) | TNKSGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6036796 | 0.82 | KDM4E (0.52) | ALDH1A1CYP3A4MAPT | |
| SCHEMBL5220493 | 0.82 | GABRP (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL5230393 | 0.80 | CA12 (0.42) | KMT2AMEN1ALDH1A1MAPTCYP2C19 | |
| SCHEMBL1864108 | 0.80 | KDM4E (0.58) | TNKSGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL1819697 | 0.76 | SLC16A3 (0.39) | KMT2AMEN1ALDH1A1CYP2C19NPSR1 | |
| SCHEMBL2318176 | 0.76 | ALDH1A1 (0.67) | TNKSGABRPGABRDGABRA1GABRB1 | |
| Hydrochloric Acid SCHEMBL8858723 | 0.75 | ALDH1A1 (0.65) | TNKSGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29120190 | 0.75 | GABRP (0.50) | TNKSGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7455688 | 0.74 | AKR1B1 (0.60) | TNKSKMT2AMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528905-B1 | PROCESS FOR THE PREPARATION OF NEBIVOLOL | CORDEN PHARMA COLORADO INC (US) | 2015-10-07 | — | — | EP | disclosed |
| EP-2528905-A1 | METHOD FOR PRODUCING NEBIVOLOL | Corden Pharmachem GmbH (DE) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011091968-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMACHEM GMBH (DE) | 2011-08-04 | — | — | WO | disclosed |