Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATF4 | P18848 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27878721 | 0.83 | FFAR4 (0.44) | FFAR4SLC6A4SLC6A2SLC6A3MEN1 | |
| SCHEMBL24658820 | 0.82 | RXRA (0.39) | ALDH1A1LMNAFFAR4POLBEPHX2 | |
| SCHEMBL28750680 | 0.79 | ALDH1A1 (0.47) | ALDH1A1FFAR4KMT2A | |
| SCHEMBL23039979 | 0.79 | ALDH1A1 (0.47) | ALDH1A1FFAR4KMT2A | |
| SCHEMBL23040236 | 0.79 | FFAR4 (0.38) | ALDH1A1FFAR4MEN1KMT2A | |
| SCHEMBL23039953 | 0.79 | FFAR4 (0.38) | ALDH1A1FFAR4MEN1KMT2A | |
| SCHEMBL3802037 | 0.78 | CTSS (0.40) | ALDH1A1LMNAFFAR4MAPTEPHX2 | |
| SCHEMBL3794151 | 0.78 | CTSS (0.40) | ALDH1A1LMNAFFAR4MAPTEPHX2 | |
| SCHEMBL29270941 | 0.77 | FFAR4 (0.39) | ALDH1A1FFAR4KMT2A | |
| SCHEMBL29270939 | 0.77 | FFAR4 (0.39) | ALDH1A1FFAR4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-01 | — | — | US | disclosed |
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-01 | — | — | US | disclosed |
| EP-3634952-A1 | CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-04-15 | — | — | EP | disclosed |
| WO-2018225093-A1 | CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | ATF4, ATF1, XBP1 | ALDH1A1 2325/4885LMNA 3667/4885LSS 4204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.