Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28405245 | 0.98 | SMN1; SMN2 (0.40) | SMN1; SMN2NISCHMEN1KMT2ACHRNB4 | |
| SCHEMBL19418197 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2NISCHMEN1KMT2ACHRNB4 | |
| SCHEMBL21156931 | 0.79 | TP53 (0.35) | SMN1; SMN2KMT2ALMNAHTTTP53 | |
| SCHEMBL28409641 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL29080929 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL15222055 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL680143 | 0.74 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL15500970 | 0.73 | CHRNB4 (0.44) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL15957201 | 0.70 | NISCH (0.42) | SMN1; SMN2NISCHMEN1KMT2ACHRNB4 | |
| SCHEMBL13490300 | 0.70 | L3MBTL1 (0.41) | SMN1; SMN2NISCHCHRNB4CHRNA3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112979660-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-06-18 | — | — | CN | disclosed |
| EP-3508484-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2021-04-07 | — | — | EP | disclosed |
| CN-107849023-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-111269221-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-06-12 | — | — | CN | disclosed |