Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29080929 | 0.99 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ARIPK1CHRNB4 | |
| SCHEMBL27312472 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL23189236 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL28405245 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL1561552 | 0.71 | RIPK1 (0.47) | RIPK1 | |
| SCHEMBL1561554 | 0.71 | RIPK1 (0.47) | RIPK1 | |
| SCHEMBL4704981 | 0.71 | RIPK1 (0.47) | RIPK1 | |
| SCHEMBL680143 | 0.71 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| SCHEMBL15222055 | 0.71 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1KMT2ACHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL2234458 | 0.70 | RIPK1 (0.46) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-112979660-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-107849023-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-03-23 | — | — | CN | disclosed |
| CN-111269221-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2020-06-12 | — | — | CN | disclosed |