SCHEMBL23194

SCHEMBL23194

[c]1cccc2c1-c1ccccc1C2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.46
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 2/20 0.39
NPC1 O15118 2/20 0.39
MAPT P10636 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
LMNA P02545 1/20 0.39
HPGD P15428 1/20 0.39
BCHE P06276 1/20 0.39
CES1 P23141 1/20 0.39
MAPK8 P45983 2/20 0.37
MAPK9 P45984 2/20 0.37
PLK4 O00444 1/20 0.37
DAPK3 O43293 1/20 0.37
PIM1 P11309 1/20 0.37
PDGFRA P16234 1/20 0.37
LTK P29376 1/20 0.37
MAP2K2 P36507 1/20 0.37
FLT3 P36888 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2796780 0.84 MAOA (0.41) MAOAALDH1A1KDM4ENPC1MAPT
SCHEMBL7765422 0.84 MAOA (0.35) MAOACYP3A4TSHRHSD17B10MAOB
SCHEMBL217954 0.79 TSHR (0.38) MAOAALDH1A1KDM4ENPC1MAPT
SCHEMBL4867512 0.79 SMN1; SMN2 (0.42) MAOAALDH1A1KDM4ENPC1MAPT
SCHEMBL6293496 0.78 CA12 (0.38) MAOACYP3A4MEN1CYP2D6KMT2A
SCHEMBL4855554 0.77 MAOA (0.40) MAOAALDH1A1KDM4ENPC1MAPT
SCHEMBL814892 0.76 KDM4E (0.36) ALDH1A1KDM4ENPC1MAPTRAB9A
SCHEMBL14744179 0.75 PNMT (0.46) MAOAALDH1A1KDM4ENPC1MAPT
SCHEMBL23903 0.74 MAOA (0.41) MAOAALDH1A1KDM4ENPC1MAPT
SCHEMBL5841463 0.74 MAOA (0.48) MAOAALDH1A1KDM4ENPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3573 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024121084-A1 PREPARATION OF NITRILES MERCK PATENT GMBH (DE) 2024-06-13 WO claimed
CN-112079786-B Compound, organic electronic light-emitting device containing compound and application of compound 北京鼎材科技有限公司 2024-05-21 CN claimed
WO-2024099269-A1 ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, USE THEREOF 华东师范大学 2024-05-16 WO claimed
CN-118044355-A Compounds for electronic devices 默克专利有限公司 2024-05-14 CN claimed
CN-118026880-A Aryl amide compound, pharmaceutical composition containing same and application thereof 华东师范大学 2024-05-14 CN claimed
CN-112094169-B Organic electroluminescent material and application thereof 北京鼎材科技有限公司 2024-03-26 CN claimed
CN-112441977-B Compound, application thereof and organic electroluminescent device comprising compound 北京鼎材科技有限公司 2024-03-19 CN claimed
US-11917906-B2 Compounds that can be used in an organic electronic device MERCK PATENT GMBH (DE) 2024-02-27 US claimed
CN-111341920-B Organic electroluminescent device 固安鼎材科技有限公司 2024-01-30 CN claimed
CN-112018248-B Display device and preparation method thereof 固安鼎材科技有限公司 2023-12-29 CN claimed
CN-1144526-A Thiazolidines and oxazolidines substituted by pyridine ring and their use a hypoglycemic agents NISSAN CHEMICAL IND LTD (JP) 1997-03-05 CN claimed
EP-0751944-A1 THIAZOLIDINES AND OXAZOLIDINES SUBSTITUTED BY A PYRIDINE RING AND THEIR USE AS HYPOGLYCEMIC AGENTS NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1997-01-08 EP claimed
WO-1995026347-A1 THIAZOLIDINES AND OXAZOLIDINES SUBSTITUTED BY A PYRIDINE RING AND THEIR USE AS HYPOGLYCEMIC AGENTS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1995-10-05 WO claimed
US-5254546-A Hypotensive agent E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-10-19 US claimed
EP-0524946-A4 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS 1993-03-24 EP claimed
EP-0524946-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-02-03 EP claimed
EP-0479892-A1 FUSED-RING ARYL SUBSTITUTED IMIDAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-04-15 EP claimed
WO-1991015206-A1 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO claimed
WO-1991014367-A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-03 WO claimed
WO-1991000281-A2 FUSED-RING ARYL SUBSTITUTED IMIDAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-01-10 WO claimed