Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23199939 | 0.85 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2GAAOPRK1NPSR1 | |
| SCHEMBL23200149 | 0.84 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2GAAOPRK1NPSR1 | |
| SCHEMBL23200239 | 0.84 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL23699903 | 0.82 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2GAAOPRK1NPSR1 | |
| SCHEMBL23200122 | 0.81 | ALDH1A1 (0.80) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA | |
| SCHEMBL23200062 | 0.80 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2GAAOPRK1NPSR1 | |
| SCHEMBL23200018 | 0.80 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2GAAOPRK1NPSR1 | |
| SCHEMBL23200047 | 0.80 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2GAAOPRK1NPSR1 | |
| SCHEMBL23199988 | 0.80 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2GAAOPRK1NPSR1 | |
| SCHEMBL23200234 | 0.79 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2NPSR1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802503-A1 | UREA DERIVATIVE MODULATORS OF TRYPTOPHAN CATABOLISM | E-Therapeutics plc (GB) | 2021-04-14 | — | — | EP | claimed |
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | E-THERAPEUTICS PLC (GB) | 2021-08-05 | — | — | US | disclosed |
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | E-THERAPEUTICS PLC (GB) | 2021-08-05 | — | — | US | disclosed |
| EP-3802503-A1 | UREA DERIVATIVE MODULATORS OF TRYPTOPHAN CATABOLISM | E-Therapeutics plc (GB) | 2021-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238139-A1 | MODULATORS OF TRYPTOPHAN CATABOLISM | TPH1, KYNU, TPH2 | ALDH1A1 606/4885SMN1; SMN2 3779/4885GAA 1248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.