Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.38 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.38 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.38 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.38 |
| ▸ | EEF2K | O00418 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8163235 | 0.88 | KCNH2 (0.51) | CNR2UTS2RKCNH2TMEM97MEN1 | |
| SCHEMBL4440361 | 0.86 | MEN1 (0.53) | CCR3UTS2RKCNH2TMEM97MEN1 | |
| SCHEMBL4428027 | 0.81 | CASR (0.48) | CCR3NPC1RAB9AUTS2RTMEM97 | |
| SCHEMBL4429764 | 0.81 | CASR (0.41) | TMEM97MEN1KMT2ALMNAALOX15 | |
| SCHEMBL4931589 | 0.80 | EEF2K (0.40) | EEF2KUTS2RMEN1KMT2A | |
| SCHEMBL4428090 | 0.79 | KCNH2 (0.41) | CCR3NPC1KCNH2TMEM97MEN1 | |
| SCHEMBL31750626 | 0.79 | EEF2K (0.41) | EEF2KUTS2R | |
| SCHEMBL22229446 | 0.77 | RIPK1 (0.37) | CNR2NPC1RAB9AEEF2KCYP2C19 | |
| SCHEMBL22229445 | 0.77 | RIPK1 (0.37) | CNR2NPC1RAB9AEEF2KCYP2C19 | |
| SCHEMBL22229447 | 0.77 | RIPK1 (0.37) | CNR2NPC1RAB9AEEF2KCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8203004-B2 | Tetrahydroindole derivatives for treatment of alzheimer's disease | MERCK, SHARP & DOHME LIMITED (GB) | 2012-06-19 | — | — | US | disclosed |
| EP-1948603-B1 | TETRAHYDROINDOLE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2011-08-10 | — | — | EP | disclosed |
| US-20100016308-A1 | Tetrahydroindole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016308-A1 | Tetrahydroindole Derivatives for Treatment of Alzheimer's Disease | BACE1, BACE2, PSEN2 | CCR3 4866/4885CNR2 656/4885NPC1 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.