Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440361 | 0.84 | MEN1 (0.53) | KCNH2MEN1KMT2ATMEM97CCR3 | |
| SCHEMBL4429764 | 0.83 | CASR (0.41) | MEN1KMT2ACASRTMEM97PPARD | |
| SCHEMBL4435446 | 0.80 | MEN1 (0.39) | KCNH2MEN1KMT2ACASRTMEM97 | |
| SCHEMBL8163235 | 0.79 | KCNH2 (0.51) | KCNH2MEN1KMT2ATMEM97 | |
| SCHEMBL4428027 | 0.79 | CASR (0.48) | MEN1KMT2ACASRTMEM97CCR3 | |
| SCHEMBL2320170 | 0.79 | CCR3 (0.42) | KCNH2MEN1KMT2ATMEM97CCR3 | |
| SCHEMBL3733476 | 0.77 | KDR (0.43) | KCNH2MCHR1MEN1KMT2AKDR | |
| SCHEMBL2714766 | 0.73 | EPHX2 (0.40) | MEN1KMT2AMAPT | |
| SCHEMBL28399788 | 0.73 | EPHX2 (0.40) | MEN1KMT2AMAPT | |
| SCHEMBL2714764 | 0.73 | EPHX2 (0.40) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |