Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440361 | 0.88 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2POLBHTT | |
| SCHEMBL4429764 | 0.85 | CASR (0.41) | CASRMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL2320170 | 0.81 | CCR3 (0.42) | MEN1KMT2AOPRK1LMNAHTT | |
| SCHEMBL4435446 | 0.79 | MEN1 (0.39) | CASRMEN1KMT2ATMEM97 | |
| SCHEMBL4428090 | 0.79 | KCNH2 (0.41) | CASRMEN1KMT2ACCR3TMEM97 | |
| SCHEMBL8163235 | 0.79 | KCNH2 (0.51) | MEN1KMT2ATMEM97UTS2R | |
| SCHEMBL4927218 | 0.78 | AOC3 (0.43) | CASROPRK1TMEM97 | |
| SCHEMBL3739840 | 0.77 | CASR (0.50) | CASRMEN1KMT2AOPRK1TACR1 | |
| SCHEMBL4432287 | 0.77 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2LMNAPOLB | |
| SCHEMBL22556982 | 0.74 | AOC3 (0.39) | CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |