Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CCR3 | P51677 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432287 | 0.88 | KMT2A (0.49) | MEN1KMT2ACCR3HTTSMN1; SMN2 | |
| SCHEMBL4428027 | 0.88 | CASR (0.48) | MEN1KMT2ACCR3HTTSMN1; SMN2 | |
| SCHEMBL8163235 | 0.86 | KCNH2 (0.51) | MEN1KMT2AKCNH2UTS2RTMEM97 | |
| SCHEMBL2320170 | 0.86 | CCR3 (0.42) | MEN1KMT2ACCR3KCNH2HTT | |
| SCHEMBL4429764 | 0.86 | CASR (0.41) | MEN1KMT2ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4428090 | 0.84 | KCNH2 (0.41) | MEN1KMT2ACCR3KCNH2MAPT | |
| SCHEMBL4435446 | 0.78 | MEN1 (0.39) | MEN1KMT2AKCNH2BACE1ACP1 | |
| SCHEMBL4931589 | 0.76 | EEF2K (0.40) | MEN1KMT2AKCNA5PDE2AUTS2R | |
| SCHEMBL4936269 | 0.76 | FAAH (0.41) | KCNA5MAPTMAPK1L3MBTL1PDE2A | |
| SCHEMBL18791305 | 0.75 | MGAT2 (0.36) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |