SCHEMBL23211607

SCHEMBL23211607

C#Cc1ccc(CN(CCOC(=O)OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)C[C@@H]2OC(C)=O)CC2CCCCN2)cc1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.35
▸ P2RY12 Q9H244 5/20 0.34
▸ NNMT P40261 1/20 0.33
▸ ADORA1 P30542 3/20 0.33
▸ PRKAB2 O43741 1/20 0.31
▸ PRKAG1 P54619 1/20 0.31
▸ PRKAA2 P54646 1/20 0.31
▸ PRKAA1 Q13131 1/20 0.31
▸ PRKAG3 Q9UGI9 1/20 0.31
▸ PRKAG2 Q9UGJ0 1/20 0.31
▸ PRKAB1 Q9Y478 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23211609 1.00 PRMT6 (0.35) PRMT6P2RY12NNMTADORA1PRKAB2
SCHEMBL23211641 0.87 PRMT6 (0.33) PRMT6P2RY12NNMTADORA1
SCHEMBL23225366 0.85 POLB (0.46) —
SCHEMBL20535013 0.85 POLB (0.46) —
SCHEMBL20535011 0.85 POLB (0.46) —
SCHEMBL23211657 0.83 KDM4E (0.49) —
SCHEMBL23211660 0.83 KDM4E (0.49) —
SCHEMBL23225375 0.83 KDM4E (0.49) —
SCHEMBL23225367 0.83 KDM4E (0.49) —
SCHEMBL23211640 0.82 PRMT6 (0.33) PRMT6ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11161869-B2 Thermally-cleavable protecting and linker groups EVONETIX LTD. (GB) 2021-11-02 — — US disclosed
US-20210107934-A1 THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS SILICON VALLEY BANK 2021-04-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210107934-A1 THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS CTDSP1, RNGTT, SSU72 PRMT6 3121/4885P2RY12 3900/4885NNMT 879/4885
US-11161869-B2 Thermally-cleavable protecting and linker groups CTDSP1, RNGTT, SSU72 PRMT6 3121/4885P2RY12 3900/4885NNMT 879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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