SCHEMBL23211641

SCHEMBL23211641

C#Cc1ccc(CN(CCOC(=O)OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)C[C@@H]2OC(C)=O)CC2CCCCN2C(=O)OCC=C)cc1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.33
▸ P2RY12 Q9H244 3/20 0.32
▸ ADORA1 P30542 1/20 0.31
▸ NNMT P40261 1/20 0.30
▸ ABL1 P00519 1/20 0.30
▸ RIN1 Q13671 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23211607 0.87 PRMT6 (0.35) PRMT6P2RY12ADORA1NNMT
SCHEMBL23211609 0.87 PRMT6 (0.35) PRMT6P2RY12ADORA1NNMT
SCHEMBL23211640 0.85 PRMT6 (0.33) PRMT6ADORA1
SCHEMBL20535601 0.82 NNMT (0.36) NNMT
SCHEMBL20535924 0.82 NNMT (0.36) NNMT
SCHEMBL23211675 0.78 KDM4E (0.49) —
SCHEMBL20535584 0.78 POLB (0.40) ABL1RIN1
SCHEMBL23211646 0.77 KDM4E (0.32) —
SCHEMBL23225354 0.77 KDM4E (0.46) —
SCHEMBL23965518 0.76 POLB (0.40) ABL1RIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11161869-B2 Thermally-cleavable protecting and linker groups EVONETIX LTD. (GB) 2021-11-02 — — US disclosed
US-20210107934-A1 THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS SILICON VALLEY BANK 2021-04-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210107934-A1 THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS CTDSP1, RNGTT, SSU72 PRMT6 3121/4885P2RY12 3900/4885ADORA1 1029/4885
US-11161869-B2 Thermally-cleavable protecting and linker groups CTDSP1, RNGTT, SSU72 PRMT6 3121/4885P2RY12 3900/4885ADORA1 1029/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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