Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21410863 | 1.00 | KDM4E (0.51) | KDM4EMEN1MAPTKMT2AJAK3 | |
| SCHEMBL21410876 | 0.88 | MAPT (0.45) | KDM4EMEN1MAPTKMT2AJAK3 | |
| SCHEMBL21410902 | 0.88 | MAPT (0.45) | KDM4EMEN1MAPTKMT2AJAK3 | |
| SCHEMBL21411176 | 0.77 | HDAC1 (0.42) | KDM4EJAK3IRAK4MAPK1HDAC1 | |
| SCHEMBL23211492 | 0.77 | HDAC1 (0.42) | KDM4EJAK3IRAK4MAPK1HDAC1 | |
| SCHEMBL27503830 | 0.77 | KMT2A (0.58) | KDM4EMEN1MAPTKMT2AJAK3 | |
| SCHEMBL8511544 | 0.76 | ANPEP (0.44) | KDM4EMEN1MAPTKMT2AHDAC1 | |
| SCHEMBL7345520 | 0.76 | MAPK1 (0.58) | KDM4EMEN1MAPTKMT2AMAPK1 | |
| SCHEMBL7348151 | 0.76 | MAPK1 (0.58) | KDM4EMEN1MAPTKMT2AMAPK1 | |
| SCHEMBL23211479 | 0.75 | LOXL2 (0.45) | KDM4EMEN1MAPTKMT2AJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174685-A1 | OX2R Compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-05-30 | — | — | US | disclosed |
| US-11905297-B2 | OX2R compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-02-20 | — | — | US | disclosed |
| US-20230122024-A1 | OX2R Compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-04-20 | — | — | US | disclosed |
| US-11479560-B2 | OX2R compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2022-10-25 | — | — | US | disclosed |
| US-11472813-B2 | OX2R compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-10-18 | — | — | US | disclosed |
| US-20210163494-A1 | OX2R Compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-06-03 | — | — | US | disclosed |
| US-20210107914-A1 | OX2R Compounds | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-15 | — | — | US | disclosed |
| CN-112165940-A | OX2R compound | 德克萨斯州立大学董事会 | 2021-01-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11479560-B2 | OX2R compounds | HCRTR2, HCRTR1, OXTR | KDM4E 1812/4885MEN1 4617/4885MAPT 1995/4885 |
| US-11905297-B2 | OX2R compounds | HCRTR2, HCRTR1, OXTR | KDM4E 1812/4885MEN1 4617/4885MAPT 1995/4885 |
| US-20240174685-A1 | OX2R Compounds | HCRTR2, HCRTR1, OXTR | KDM4E 1812/4885MEN1 4617/4885MAPT 1995/4885 |
| US-20210107914-A1 | OX2R Compounds | HCRTR2, HCRTR1, OXTR | KDM4E 1812/4885MEN1 4617/4885MAPT 1995/4885 |
| US-20230122024-A1 | OX2R Compounds | HCRTR2, HCRTR1, OXTR | KDM4E 1812/4885MEN1 4617/4885MAPT 1995/4885 |
| US-11472813-B2 | OX2R compounds | HCRTR2, HCRTR1, OXTR | KDM4E 1812/4885MEN1 4617/4885MAPT 1995/4885 |
| US-20210163494-A1 | OX2R Compounds | HCRTR2, HCRTR1, OXTR | KDM4E 1812/4885MEN1 4617/4885MAPT 1995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.