Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16468436 | 0.75 | LTA4H (0.47) | LMNAKMT2AMEN1LTA4HNAPRT | |
| SCHEMBL17188100 | 0.72 | TSHR (0.42) | MAPK1ALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL28167045 | 0.71 | ALDH1A1 (0.33) | LMNAKMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL29853983 | 0.69 | MEN1 (0.46) | LMNAKMT2AMEN1LTA4HNAPRT | |
| SCHEMBL23215137 | 0.69 | MEN1 (0.46) | LMNAKMT2AMEN1LTA4HNAPRT | |
| SCHEMBL725064 | 0.69 | KMT2A (0.80) | LMNAKMT2AMEN1LTA4HNAPRT | |
| SCHEMBL23216806 | 0.68 | JAK1 (0.44) | LMNAKMT2AMEN1LTA4HNAPRT | |
| SCHEMBL1969488 | 0.67 | ALDH1A1 (0.39) | KMT2AMEN1POLBALDH1A1ALPL | |
| SCHEMBL5622548 | 0.67 | ALPL (0.37) | LMNAKMT2AMEN1ALDH1A1ALPL | |
| SCHEMBL7452087 | 0.67 | RAB9A (0.49) | LMNAKMT2AMEN1LTA4HPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114727992-A | Arylmethylene aromatic compounds as Kv1.3 potassium Shaker channel blockers | D·E·萧尔研究有限责任公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021071821-A1 | ARYLMETHYLENE AROMATIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS | D.E. SHAW RESEARCH, LLC (US) | 2021-04-15 | — | — | WO | disclosed |