Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217016 | 0.88 | HTT (0.60) | MAPTALDH1A1KDM4EPOLBHTT | |
| SCHEMBL23217034 | 0.88 | MAPT (0.57) | MAPTALDH1A1KDM4EPOLBHTT | |
| SCHEMBL30889350 | 0.88 | MAPT (0.57) | MAPTALDH1A1KDM4EPOLBHTT | |
| SCHEMBL1870289 | 0.87 | F13A1 (0.72) | MAPTALDH1A1HTTLMNAGAA | |
| SCHEMBL25381894 | 0.86 | MAPT (0.66) | MAPTALDH1A1KDM4EKDM4CTDP1 | |
| SCHEMBL30563199 | 0.86 | MAPT (0.66) | MAPTALDH1A1KDM4EKDM4CTDP1 | |
| SCHEMBL30889354 | 0.86 | ALDH1A1 (0.58) | MAPTALDH1A1KDM4EPOLBKDM4C | |
| SCHEMBL23217102 | 0.86 | ALDH1A1 (0.58) | MAPTALDH1A1KDM4EPOLBKDM4C | |
| SCHEMBL30006605 | 0.84 | TRPV4 (0.57) | MAPTALDH1A1KDM4EPOLBHTT | |
| SCHEMBL30005853 | 0.84 | TRPV4 (0.57) | MAPTALDH1A1KDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124400-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2024-04-18 | — | — | US | disclosed |
| WO-2021072369-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072369-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124400-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | CFH, LPAR3, CBR3 | MAPT 4754/4885ALDH1A1 3931/4885KDM4E 2296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.