Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 4/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24311930 | 0.86 | L3MBTL1 (0.43) | DGAT1 | |
| SCHEMBL2150010 | 0.81 | HIF1A (0.47) | HIF1ADGAT1ALDH1A1 | |
| SCHEMBL13275325 | 0.81 | LPL (0.41) | HIF1ADGAT1ALPLSNCAEGFR | |
| SCHEMBL23217904 | 0.81 | CA1 (0.41) | HIF1ADGAT1ALDH1A1ALPL | |
| SCHEMBL13274885 | 0.80 | SNCA (0.41) | DGAT1ALDH1A1F2GLAHPGD | |
| SCHEMBL2220666 | 0.78 | SNCA (0.40) | HIF1ADGAT1ALDH1A1F2GLA | |
| SCHEMBL1561011 | 0.78 | HIF1A (0.47) | HIF1AF2HPGD | |
| SCHEMBL23217957 | 0.77 | KDM4E (0.40) | PDE2APDE3BPDE3AALDH1A1F2 | |
| SCHEMBL16612477 | 0.76 | L3MBTL1 (0.46) | HIF1AALDH1A1HPGD | |
| SCHEMBL20392825 | 0.75 | SNCA (0.50) | DGAT1ALDH1A1F2GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |