Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | GCG | P01275 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 3/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24311927 | 0.85 | HPGDS (0.41) | CA1CA2CA9HPGDSDGAT1 | |
| SCHEMBL23218017 | 0.81 | HIF1A (0.39) | DGAT1HIF1AALDH1A1ALPL | |
| SCHEMBL3451006 | 0.80 | ALOX15 (0.44) | HPGDSCXCR2DGAT1HIF1AALDH1A1 | |
| SCHEMBL23218010 | 0.77 | CA1 (0.38) | CA1CA2CA9CXCR2DGAT1 | |
| SCHEMBL26623600 | 0.77 | P4HB (0.38) | CXCR2DGAT1HIF1AALPL | |
| SCHEMBL20392741 | 0.74 | CYP1A2 (0.45) | HIF1AALPL | |
| SCHEMBL26623561 | 0.73 | RAB9A (0.54) | DGAT1ALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL23262307 | 0.73 | HTT (0.50) | DGAT1ALDH1A1MAPTMAPK1ALPL | |
| SCHEMBL2144110 | 0.72 | MTNR1A (0.49) | CA1CA2CA9DGAT1HIF1A | |
| SCHEMBL30657968 | 0.71 | DGAT1 (0.39) | CA1CA2CA9DGAT1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072330-A1 | GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES | SILVERBACK THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |