Sugi Predict

Sugi Predict / Compounds / SCHEMBL23218037

SCHEMBL23218037

SCHEMBL23218037

CCOC(=O)Cc1ccc(OC)cc1OCc1coc2c(C)cc(-c3cccc(CN)c3)cc12

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MTNR1A P48039 4/20 0.43
▸ MTNR1B P49286 4/20 0.43
▸ CFD P00746 4/20 0.42
▸ PLG P00747 2/20 0.40
▸ PLAU P00749 2/20 0.40
▸ F11 P03951 1/20 0.40
▸ KLKB1 P03952 1/20 0.40
▸ F7 P08709 1/20 0.40
▸ TPSB2 P20231 1/20 0.40
▸ FFAR1 O14842 2/20 0.38
▸ KDM4E B2RXH2 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ PSMB5 P28074 1/20 0.36
▸ DPP4 P27487 2/20 0.35
▸ PTGER4 P35408 1/20 0.35
▸ MAPT P10636 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29852911 1.00 MTNR1A (0.43) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL23218408 0.94 CFD (0.42) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL29852732 0.94 CFD (0.42) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL29592519 0.91 CFD (0.50) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL23218511 0.91 CFD (0.44) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL29852621 0.91 CFD (0.44) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL23218240 0.91 CFD (0.50) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL23218472 0.91 MTNR1A (0.41) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL29852432 0.91 MTNR1A (0.41) MTNR1AMTNR1BCFDPLGPLAU
SCHEMBL23218258 0.90 CFD (0.40) MTNR1AMTNR1BCFDPLGPLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12558341-B2 Oral complement factor D inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2026-02-24 — — US disclosed
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-06-12 — — US disclosed
CN-114502168-A Oral complement factor D inhibitors 拜奥克里斯特制药公司 2022-05-13 — — CN disclosed
WO-2021072198-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 — — WO disclosed
WO-2021072198-A1 ORAL COMPLEMENT FACTOR D INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2021-04-15 — — WO disclosed
US-20160361275-A1 SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY ACADIA PHARMACEUTICALS INC. 2016-12-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160361275-A1 SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY SLC6A4, HTR4, GPR34 MTNR1A 678/4885MTNR1B 514/4885CFD 4300/4885
US-12558341-B2 Oral complement factor D inhibitors CFD, CFH, CFB MTNR1A 3930/4885MTNR1B 3580/4885CFD 1/4885
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS CFD, CFH, CFB MTNR1A 3848/4885MTNR1B 2984/4885CFD 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.