Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218949 | 0.90 | TBXAS1 (0.41) | TBXAS1MTNR1AMAPTNPSR1PSMB5 | |
| SCHEMBL8175604 | 0.84 | MEN1 (0.47) | MTNR1AMAPTMEN1POLBKMT2A | |
| SCHEMBL31425808 | 0.84 | MEN1 (0.47) | MTNR1AMAPTMEN1POLBKMT2A | |
| SCHEMBL23218059 | 0.82 | CYP4F2 (0.44) | MTNR1AMAPTNPSR1MEN1POLB | |
| SCHEMBL23218366 | 0.82 | CFD (0.49) | TBXAS1MTNR1APSMB5TP53 | |
| SCHEMBL29852811 | 0.82 | MAPT (0.46) | TBXAS1MAPTNPSR1MEN1POLB | |
| SCHEMBL23218748 | 0.82 | MAPT (0.46) | TBXAS1MAPTNPSR1MEN1POLB | |
| Methylene Chloride SCHEMBL8520941 | 0.81 | MEN1 (0.45) | MTNR1AMAPTMEN1POLBKMT2A | |
| SCHEMBL23218697 | 0.80 | MAPT (0.40) | MAPTNPSR1MEN1POLBKMT2A | |
| SCHEMBL29852717 | 0.80 | MAPT (0.40) | MAPTNPSR1MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |