Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29853032 | 1.00 | ELANE (0.50) | ELANECYSLTR1NR1H4MRGPRX4MAOB | |
| SCHEMBL29593262 | 1.00 | ELANE (0.50) | ELANECYSLTR1NR1H4MRGPRX4MAOB | |
| SCHEMBL28736134 | 0.90 | MRGPRX4 (0.48) | ELANECYSLTR1MRGPRX4MAOBMAOA | |
| SCHEMBL23218892 | 0.85 | NLRP3 (0.40) | ELANEMRGPRX4MAOBMAOASMPD1 | |
| SCHEMBL29852680 | 0.83 | LOXL2 (0.46) | CYSLTR1NR1H4MRGPRX4VDR | |
| SCHEMBL23218806 | 0.83 | LOXL2 (0.46) | CYSLTR1NR1H4MRGPRX4VDR | |
| SCHEMBL23229140 | 0.76 | NLRP3 (0.38) | ELANELMNASMN1; SMN2TSHRNLRP3 | |
| SCHEMBL23218901 | 0.75 | ALDH1A1 (0.44) | ELANEKDM4EHSD17B10POLBNLRP3 | |
| SCHEMBL23218861 | 0.74 | PTGER1 (0.40) | ELANEKDM4ELMNASMN1; SMN2TSHR | |
| SCHEMBL29591284 | 0.74 | PTGER1 (0.40) | ELANEKDM4ELMNASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |