Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852680 | 1.00 | LOXL2 (0.46) | LOXL2MRGPRX4CFDVDRCYSLTR1 | |
| SCHEMBL23219181 | 0.91 | NR4A2 (0.50) | LOXL2MRGPRX4CFDNR4A2NR1H4 | |
| SCHEMBL29591762 | 0.91 | NR4A2 (0.50) | LOXL2MRGPRX4CFDNR4A2NR1H4 | |
| SCHEMBL23218903 | 0.88 | CFD (0.42) | CFDVDRADAMTS4PLAUSSTR5 | |
| SCHEMBL23218710 | 0.86 | CFD (0.50) | CFDNR4A2NR1H4PLAUSSTR5 | |
| SCHEMBL29853032 | 0.83 | ELANE (0.50) | MRGPRX4VDRCYSLTR1NR1H4 | |
| SCHEMBL29593262 | 0.83 | ELANE (0.50) | MRGPRX4VDRCYSLTR1NR1H4 | |
| SCHEMBL23218589 | 0.83 | ELANE (0.50) | MRGPRX4VDRCYSLTR1NR1H4 | |
| SCHEMBL23219231 | 0.79 | PLG (0.46) | CFDVDRPLAUF2 | |
| SCHEMBL23219055 | 0.78 | CFD (0.45) | CFDPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |