Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29593254 | 1.00 | AKR1C3 (0.37) | AKR1C3CD274CFDPDE10ASCN9A | |
| SCHEMBL23218950 | 0.92 | DPP4 (0.39) | CFDPDE10ASCN9ACSF1RPDGFRB | |
| SCHEMBL29852921 | 0.92 | DPP4 (0.39) | CFDPDE10ASCN9ACSF1RPDGFRB | |
| SCHEMBL29591865 | 0.90 | CFD (0.43) | AKR1C3CD274CFDSCN9AP2RX3 | |
| SCHEMBL23218951 | 0.90 | CFD (0.43) | AKR1C3CD274CFDSCN9AP2RX3 | |
| SCHEMBL23218722 | 0.86 | CSF1R (0.34) | AKR1C3CFDPDE10ASCN9ACSF1R | |
| SCHEMBL29592684 | 0.85 | CFD (0.37) | AKR1C3CFDPDE10ACSF1RPDGFRB | |
| SCHEMBL23218690 | 0.85 | CFD (0.37) | AKR1C3CFDPDE10ACSF1RPDGFRB | |
| SCHEMBL28736114 | 0.83 | AKR1C3 (0.33) | AKR1C3CFDSCN9ACSF1RPDGFRB | |
| SCHEMBL29121568 | 0.83 | P2RX3 (0.37) | AKR1C3CD274CFDSCN9ACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |