Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 13/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29852433 | 1.00 | CFD (0.47) | CFDTBXAS1DPP4TP53MAPT | |
| SCHEMBL23229055 | 0.90 | CFD (0.40) | CFDTBXAS1TP53MAPTTHRB | |
| SCHEMBL29592511 | 0.89 | CFD (0.56) | CFDPLGPLAUF11KLKB1 | |
| SCHEMBL23218509 | 0.89 | CFD (0.56) | CFDPLGPLAUF11KLKB1 | |
| SCHEMBL23219180 | 0.88 | CFD (0.50) | CFDPLGPLAUF11KLKB1 | |
| SCHEMBL21438156 | 0.88 | CFD (0.48) | CFDTBXAS1DPP4PLGPLAU | |
| SCHEMBL29853039 | 0.88 | CFD (0.50) | CFDPLGPLAUF11KLKB1 | |
| SCHEMBL29591368 | 0.88 | CFD (0.50) | CFDPLGPLAUF11KLKB1 | |
| SCHEMBL29852577 | 0.86 | CFD (0.37) | CFDTBXAS1TP53MAPTTHRB | |
| SCHEMBL23219245 | 0.86 | CFD (0.50) | CFDTBXAS1DPP4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |