Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31615139 | 1.00 | GABRA1 (0.36) | GABRA1GABRB1GABRA3GABRB2ALDH1A1 | |
| SCHEMBL28736162 | 0.87 | HDAC3 (0.33) | LSSHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29852836 | 0.85 | ABCB11 (0.38) | GABRA1GABRB1GABRA3GABRB2ALDH1A1 | |
| SCHEMBL23218323 | 0.85 | ABCB11 (0.38) | GABRA1GABRB1GABRA3GABRB2ALDH1A1 | |
| SCHEMBL29852641 | 0.84 | GABRA1 (0.42) | GABRA1GABRB1GABRA3GABRB2ALDH1A1 | |
| SCHEMBL23218592 | 0.84 | GABRA1 (0.42) | GABRA1GABRB1GABRA3GABRB2ALDH1A1 | |
| SCHEMBL23218799 | 0.79 | ADRA2A (0.32) | LMNAHIF1AHDAC3HDAC1HDAC2 | |
| SCHEMBL29591636 | 0.79 | ADRA2A (0.32) | LMNAHIF1AHDAC3HDAC1HDAC2 | |
| SCHEMBL23218838 | 0.78 | ALDH1A1 (0.42) | GABRA1GABRB1GABRA3GABRB2ALDH1A1 | |
| SCHEMBL29853260 | 0.78 | ALDH1A1 (0.42) | GABRA1GABRB1GABRA3GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502168-A | Oral complement factor D inhibitors | 拜奥克里斯特制药公司 | 2022-05-13 | — | — | CN | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021072198-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2021-04-15 | — | — | WO | disclosed |