Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571903 | 0.82 | ADRB1 (0.40) | ADRB1ADRB2ADRB3JAK2JAK3 | |
| SCHEMBL9451750 | 0.81 | LSS (0.47) | ADRB1ADRB2ADRB3JAK2JAK3 | |
| SCHEMBL9451561 | 0.79 | DRD3 (0.46) | ADRB1ADRB2ADRB3JAK2JAK3 | |
| SCHEMBL7301452 | 0.79 | JAK2 (0.64) | ADRB1ADRB2ADRB3JAK2JAK3 | |
| SCHEMBL28704613 | 0.79 | JAK2 (0.49) | ADRB1ADRB2ADRB3JAK2JAK3 | |
| SCHEMBL5547166 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7307376 | 0.77 | MCHR1 (0.53) | ADRB1ADRB2ADRB3NR3C2SMN1; SMN2 | |
| SCHEMBL8728925 | 0.76 | ADRB1 (0.46) | ADRB1GPR119SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7302740 | 0.76 | JAK2 (0.44) | ADRB1ADRB2ADRB3JAK2JAK3 | |
| SCHEMBL7319744 | 0.76 | KDM4E (0.48) | ADRB1ADRB2ADRB3JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4297456-A | — | — | None | — | — | JP | disclosed |
| EP-2600863-B1 | USE OF SIGMA LIGANDS IN OPIOID-INDUCED HYPERALGESIA | ESTEVE LABOR DR (ES) | 2018-03-28 | — | — | EP | disclosed |
| EP-2646025-B1 | USE OF SIGMA LIGANDS IN BONE CANCER PAIN | ESTEVE LABOR DR (ES) | 2017-03-15 | — | — | EP | disclosed |
| EP-2571501-B1 | SIGMA LIGANDS FOR THE PREVENTION AND/OR TREATMENT OF EMESIS INDUCED BY CHEMOTHERAPY OR RADIOTHERAPY | ESTEVE LABOR DR (ES) | 2016-03-02 | — | — | EP | disclosed |
| EP-2460519-A1 | Use of sigma ligands in bone cancer pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2012-06-06 | — | — | EP | disclosed |
| EP-2353598-A1 | Sigma ligands for use in the prevention and/or treatment of postoperative pain | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2011-08-10 | — | — | EP | disclosed |
| EP-0481288-B1 | 1-Phenylpiperid-4-ylamines and drugs containing them | BASF AG (DE) | 1995-07-26 | — | — | EP | disclosed |
| US-5175174-A | PHENYLPIPERIDINYLAMINES AND DRUGS CONTAINING THESE | BASF AKTIENGESELLSCHAFT (DE) | 1992-12-29 | — | — | US | disclosed |
| JP-H04297456-A | PHENYLPIPERIDINYLAMINE | BASF AG | 1992-10-21 | — | — | JP | disclosed |
| EP-0481288-A2 | 1-Phenylpiperid-4-ylamines and drugs containing them | BASF Aktiengesellschaft (DE) | 1992-04-22 | — | — | EP | disclosed |