Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.64 |
| ▸ | JAK3 | P52333 | 3/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28046254 | 0.91 | JAK2 (0.56) | JAK2JAK3PTK2ADRB1ADRB2 | |
| SCHEMBL28704613 | 0.84 | JAK2 (0.49) | JAK2JAK3ADRB1ADRB2ADRB3 | |
| SCHEMBL28824858 | 0.82 | MAPT (0.60) | ALDH1A1MAPTRECQLSMN1; SMN2EPHX2 | |
| SCHEMBL16261606 | 0.80 | MAPT (0.63) | ALDH1A1MAPTRECQLSMN1; SMN2EPHX2 | |
| SCHEMBL3957543 | 0.80 | JAK2 (1.00) | JAK2JAK3HDAC1 | |
| SCHEMBL4500240 | 0.79 | GPR119 (0.58) | JAK2JAK3 | |
| SCHEMBL10426116 | 0.79 | ALDH1A1 (0.59) | JAK2JAK3PTK2ADRB1ADRB2 | |
| SCHEMBL2321959 | 0.79 | ADRB1 (0.45) | JAK2JAK3ADRB1ADRB2ADRB3 | |
| SCHEMBL8781158 | 0.78 | HTR6 (0.61) | PTK2ADRB1ADRB2ADRB3ALDH1A1 | |
| SCHEMBL5851742 | 0.78 | HTR6 (0.64) | PTK2ADRB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481299-B1 | N-phenyl-piperidyl-4-amines and drugs containing them | BASF AG (DE) | 1994-07-20 | — | — | EP | disclosed |
| US-5260318-A | Phenylpiperidylamines and drugs containing them | BASF AKTIENGESELLSCHAFT (DE) | 1993-11-09 | — | — | US | disclosed |
| EP-0481299-A2 | N-phenyl-piperidyl-4-amines and drugs containing them | BASF Aktiengesellschaft (DE) | 1992-04-22 | — | — | EP | disclosed |