Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23353355 | 0.85 | RIPK1 (0.53) | RIPK1 | |
| SCHEMBL20645895 | 0.71 | RIPK1 (0.53) | RIPK1 | |
| SCHEMBL29297718 | 0.70 | RIPK1 (0.55) | RIPK1 | |
| SCHEMBL20641354 | 0.67 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL20282755 | 0.67 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL20640707 | 0.67 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL20641152 | 0.66 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL20641170 | 0.66 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL20640858 | 0.66 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL30721474 | 0.66 | RIPK1 (1.00) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834461-B2 | Bicyclic ketone compounds and methods of use thereof | GENENTECH, INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20210139504-A1 | BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2021-05-13 | — | — | US | disclosed |
| US-10975095-B2 | — | — | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139504-A1 | BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF | HSD17B7, CYP11B1, CYP11B2 | RIPK1 3489/4885 |
| US-10975095-B2 | — | CYP1B1, UGT1A1, CYP4B1 | RIPK1 4628/4885 |
| US-11834461-B2 | Bicyclic ketone compounds and methods of use thereof | HSD17B7, CYP11B1, CYP11B2 | RIPK1 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.