Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21607430 | 1.00 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2RECQLESR1ESR2 | |
| SCHEMBL23220056 | 1.00 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2RECQLESR1ESR2 | |
| SCHEMBL21598024 | 0.83 | NPSR1 (0.36) | — | |
| SCHEMBL23220025 | 0.83 | NPSR1 (0.36) | — | |
| SCHEMBL102472 | 0.81 | POLB (0.41) | ALDH1A1SMN1; SMN2GAAKMT2ATSHR | |
| SCHEMBL21598371 | 0.78 | — | — | |
| SCHEMBL3523 | 0.77 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2GAAKMT2ATSHR | |
| SCHEMBL2879833 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2GAAKMT2ATSHR | |
| SCHEMBL2505 | 0.76 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2KMT2ATSHR | |
| SCHEMBL23220067 | 0.75 | ALDH1A1 (0.36) | ALDH1A1RECQLHTTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975037-B2 | Phenyl substituted pyrazoles as modulators of RORγt | RORC, RORB, RORA | ALDH1A1 801/4885SMN1; SMN2 4508/4885RECQL 828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.