Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2322209 | 0.77 | ALDH1A1 (0.67) | ALDH1A1LMNACYP1A2HIF1ASMN1; SMN2 | |
| SCHEMBL29739306 | 0.68 | ALDH1A1 (0.54) | ALDH1A1LMNACYP1A2SMN1; SMN2GAA | |
| 4-Cyanophenyl Phenylcarbamate SCHEMBL10393666 | 0.66 | ALDH1A1 (0.64) | ALDH1A1LMNACYP1A2SMN1; SMN2GAA | |
| SCHEMBL8822110 | 0.66 | ALDH1A1 (0.51) | ALDH1A1HSD17B10SMN1; SMN2GAAHTT | |
| SCHEMBL27794530 | 0.65 | ALDH1A1 (0.54) | ALDH1A1LMNASMN1; SMN2GAAHTT | |
| SCHEMBL6630173 | 0.64 | KDM4E (0.64) | ALDH1A1SMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL20064247 | 0.64 | ALDH1A1 (0.43) | ALDH1A1LMNACYP1A2HSD17B10SMN1; SMN2 | |
| SCHEMBL11796988 | 0.64 | ALDH1A1 (0.56) | ALDH1A1TSHRSMN1; SMN2GAAHTT | |
| SCHEMBL8048675 | 0.64 | NOTUM (0.59) | ALDH1A1SMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL4676605 | 0.64 | ALDH1A1 (0.49) | ALDH1A1LMNACYP1A2HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531508-A1 | PYRROLO [ 2, 3 - D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | Pfizer Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| US-20120309776-A1 | PYRROLO[2,3-D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | PFITZER INC. | 2012-12-06 | — | — | US | disclosed |
| WO-2011097087-A1 | PYRROLO [ 2, 3 - D] PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | PFIZER INC. (US) | 2011-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309776-A1 | PYRROLO[2,3-D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | JAK3, JAK1, JAK2 | ALDH1A1 3377/4885LMNA 4753/4885CYP1A2 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.