Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011568 | 0.82 | IDO1 (0.54) | ALDH1A1LMNACYP1A2HTTEPHX2 | |
| SCHEMBL2322207 | 0.77 | ALDH1A1 (0.53) | ALDH1A1LMNACYP1A2HIF1AHTT | |
| SCHEMBL20064247 | 0.74 | ALDH1A1 (0.43) | ALDH1A1LMNACYP1A2HTTIDO1 | |
| SCHEMBL15890232 | 0.74 | BRD4 (0.53) | ALDH1A1LMNACYP1A2HTTIDO1 | |
| SCHEMBL24096902 | 0.74 | IDO1 (0.48) | ALDH1A1LMNACYP1A2HTTIDO1 | |
| SCHEMBL29739306 | 0.73 | ALDH1A1 (0.54) | ALDH1A1LMNACYP1A2HTTMAPT | |
| SCHEMBL27785458 | 0.72 | EDNRA (0.50) | ALDH1A1IDO1EDNRA | |
| SCHEMBL19563752 | 0.71 | IDO1 (0.60) | ALDH1A1LMNACYP1A2HTTIDO1 | |
| SCHEMBL1011299 | 0.71 | ALDH1A1 (0.44) | ALDH1A1LMNACYP1A2HTTIDO1 | |
| SCHEMBL897183 | 0.70 | RAB9A (0.61) | ALDH1A1LMNACYP1A2SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531508-A1 | PYRROLO [ 2, 3 - D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | Pfizer Inc. (US) | 2012-12-12 | — | — | EP | disclosed |
| US-20120309776-A1 | PYRROLO[2,3-D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | PFITZER INC. | 2012-12-06 | — | — | US | disclosed |
| WO-2011097087-A1 | PYRROLO [ 2, 3 - D] PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | PFIZER INC. (US) | 2011-08-11 | — | — | WO | disclosed |
| EP-0044185-A2 | Imidazolidinone derivatives | ELI LILLY AND COMPANY (US) | 1982-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309776-A1 | PYRROLO[2,3-D]PYRIMIDINE UREA COMPOUNDS AS JAK INHIBITORS | JAK3, JAK1, JAK2 | ALDH1A1 3377/4885LMNA 4753/4885CYP1A2 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.