Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NEDD4 | P46934 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28033467 | 0.77 | KDM4E (0.50) | KDM4EPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL17141945 | 0.74 | KDM4E (0.81) | KDM4EPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL16828161 | 0.74 | ALDH1A1 (0.54) | KDM4EALDH1A1SMN1; SMN2GAAHTT | |
| SCHEMBL11796988 | 0.73 | ALDH1A1 (0.56) | KDM4EPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL27828414 | 0.73 | MAPT (0.66) | KDM4EPOLBSMN1; SMN2NEDD4RAB9A | |
| SCHEMBL6632141 | 0.72 | L3MBTL1 (0.50) | KDM4EPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5652651 | 0.72 | L3MBTL1 (0.48) | KDM4EALDH1A1SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL59717 | 0.71 | RAB9A (0.55) | POLBALDH1A1SMN1; SMN2GAAHTT | |
| SCHEMBL9525680 | 0.71 | HTT (0.43) | KDM4EALDH1A1SMN1; SMN2GAAHTT | |
| SCHEMBL16852130 | 0.71 | RAB9A (0.47) | KDM4EALDH1A1SMN1; SMN2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |