Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932048 | 0.87 | MAPT (0.46) | ALDH1A1HSD17B10GAAHTTSMN1; SMN2 | |
| SCHEMBL6931877 | 0.86 | THRB (0.48) | GAAHTTSMN1; SMN2KDM4EBLM | |
| SCHEMBL6937152 | 0.82 | CA1 (0.40) | HTTSMN1; SMN2BLMRAB9AATM | |
| SCHEMBL7783570 | 0.82 | DHODH (0.63) | HTTSMN1; SMN2BLMKMT2ARAB9A | |
| SCHEMBL6936296 | 0.82 | RAB9A (0.39) | HTTSMN1; SMN2BLMKMT2ARAB9A | |
| SCHEMBL10643669 | 0.80 | NPC1 (0.38) | ALDH1A1HSD17B10HTTSMN1; SMN2BLM | |
| SCHEMBL10648551 | 0.79 | SMN1; SMN2 (0.44) | ALDH1A1HTTSMN1; SMN2BLMKMT2A | |
| SCHEMBL10646741 | 0.78 | DHODH (0.43) | HTTSMN1; SMN2BLMKMT2ARAB9A | |
| SCHEMBL10644685 | 0.76 | NPC1 (0.41) | HTTSMN1; SMN2BLMRAB9ANPC1 | |
| SCHEMBL3650040 | 0.76 | LMNA (0.35) | ALDH1A1HSD17B10HTTSMN1; SMN2BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413329-B1 | 5-Methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseases | ALCON LAB INC (US) | 1997-02-05 | — | — | EP | disclosed |
| EP-0413329-A2 | 5-Methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for the treatment of ocular diseases | ALCON LABORATORIES, INC. (US) | 1991-02-20 | — | — | EP | disclosed |
| EP-0013376-B1 | ISOXAZOLE DERIVATIVE, PROCESS FOR ITS PREPARATION AND COMPOSITION CONTAINING IT | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-19 | — | — | EP | disclosed |