Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 17/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23209150 | 0.87 | TRPA1 (0.53) | TRPA1 | |
| SCHEMBL23209149 | 0.87 | TRPA1 (0.53) | TRPA1 | |
| SCHEMBL23239259 | 0.86 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL24689347 | 0.86 | TRPA1 (0.42) | TRPA1 | |
| SCHEMBL24689137 | 0.85 | MAPT (0.45) | TRPA1 | |
| SCHEMBL23237637 | 0.80 | TRPA1 (0.47) | TRPA1 | |
| SCHEMBL23237543 | 0.77 | TRPA1 (0.45) | TRPA1 | |
| SCHEMBL23239264 | 0.77 | TRPA1 (0.49) | TRPA1SMN1; SMN2 | |
| SCHEMBL25968549 | 0.76 | TRPA1 (0.55) | TRPA1 | |
| SCHEMBL18704236 | 0.75 | TRPA1 (0.53) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858921-B2 | Uracil derivatives as TRPA1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-11858921-B2 | Uracil derivatives as TRPA1 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-01-02 | — | — | US | disclosed |
| US-20220340590-A1 | 3H,4H-THIENO[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-10-27 | — | — | US | disclosed |
| US-11136336-B2 | Thienopyrimidones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-10-05 | — | — | US | disclosed |
| US-20210107918-A1 | Novel Thienopyrimidones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210107918-A1 | Novel Thienopyrimidones | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885SMN1; SMN2 1490/4885NPSR1 1267/4885 |
| US-20220340590-A1 | 3H,4H-THIENO[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES AS TRPA1 INHIBITORS | TRPA1, TRPV1, TRPV3 | TRPA1 1/4885SMN1; SMN2 1114/4885NPSR1 285/4885 |
| US-11858921-B2 | Uracil derivatives as TRPA1 inhibitors | TRPA1, TRPV1, TRPM6 | TRPA1 1/4885SMN1; SMN2 962/4885NPSR1 1363/4885 |
| US-11136336-B2 | Thienopyrimidones | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885SMN1; SMN2 1670/4885NPSR1 1249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.