Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.55 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.55 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.49 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | GRM6 | O15303 | 3/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.49 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.49 |
| ▸ | GRM8 | O00222 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.49 |
| ▸ | GSR | P00390 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R,S)-Ampa SCHEMBL19086372 | 1.00 | GRIA1 (0.58) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| (R,S)-Ampa SCHEMBL68799 | 0.90 | GRIA1 (0.69) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| (R,S)-Ampa SCHEMBL2458874 | 0.90 | GRIA1 (0.69) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| (S)-Ampa SCHEMBL667915 | 0.90 | GRIA1 (0.69) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| (R,S)-Ampa SCHEMBL7200262 | 0.89 | GRIA1 (0.68) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| (R,S)-Ampa SCHEMBL7200264 | 0.89 | GRIA1 (0.68) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| (R,S)-Ampa SCHEMBL6553747 | 0.87 | GRIA1 (0.56) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| SCHEMBL3731488 | 0.81 | GRIA1 (0.54) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| SCHEMBL12506417 | 0.81 | GRIA1 (0.54) | GRIA1GRIA3GRIA2GRIA4GRIK1 | |
| (S)-Ampa SCHEMBL28091565 | 0.80 | GRIA1 (0.53) | GRIA1GRIA3GRIA2GRIA4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3580213-B1 | AMPA RECEPTOR POTENTIATORS | UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) | 2024-03-27 | — | — | EP | disclosed |
| EP-3759092-B1 | COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION | UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) | 2023-12-20 | — | — | EP | disclosed |
| US-20230000847-A1 | COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION | DRAIG THERAPEUTICS LTD (GB) | 2023-01-05 | — | — | US | disclosed |
| CN-110520418-B | AMPA receptor potentiators | 加的夫大学学院咨询有限公司 | 2022-08-16 | — | — | CN | disclosed |
| US-11298345-B2 | Compounds that modulates AMPA receptor function | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2022-04-12 | — | — | US | disclosed |
| CN-113891891-A | Modulators of AMPA receptor signaling | 戒毒及精神健康中心 | 2022-01-04 | — | — | CN | disclosed |
| US-11186567-B2 | AMPA receptor potentiators | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2021-11-30 | — | — | US | disclosed |
| CN-107075485-B | Corneal endothelial cell markers | 国立大学法人大阪大学 | 2021-10-01 | — | — | CN | disclosed |
| US-20210139463-A1 | AMPA RECEPTOR POTENTIATORS | DRAIG THERAPEUTICS LTD (GB) | 2021-05-13 | — | — | US | disclosed |
| US-20210113539-A1 | COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION | DRAIG THERAPEUTICS LTD (GB) | 2021-04-22 | — | — | US | disclosed |
| CN-112004811-A | Compounds that modulate AMPA receptor function | 加的夫大学学院咨询有限公司 | 2020-11-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139463-A1 | AMPA RECEPTOR POTENTIATORS | GRIN1, GRM1, GRM2 | GRIA1 6/4885GRIA3 22/4885GRIA2 12/4885 |
| US-20230000847-A1 | COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION | GRIN1, GRM1, GRIN2A | GRIA1 6/4885GRIA3 25/4885GRIA2 11/4885 |
| US-20210113539-A1 | COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION | GRIN1, GRM1, GRIN2A | GRIA1 6/4885GRIA3 25/4885GRIA2 11/4885 |
| US-11298345-B2 | Compounds that modulates AMPA receptor function | GRIN1, GRM1, GRIN2A | GRIA1 6/4885GRIA3 25/4885GRIA2 11/4885 |
| US-11186567-B2 | AMPA receptor potentiators | GRIN1, GRM1, GRM2 | GRIA1 6/4885GRIA3 22/4885GRIA2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.