(R,S)-Ampa

(R,S)-Ampa

SCHEMBL23242452

Cc1onc(O)c1CC(N)C(=O)O.NC(CCC(=O)O)C(=O)O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 6/20 0.58
GRIA3 P42263 6/20 0.58
GRIA2 P42262 5/20 0.55
GRIA4 P48058 5/20 0.55
GRIK1 P39086 3/20 0.49
GRIK5 Q16478 3/20 0.49
CYP1A2 P05177 3/20 0.49
GRM6 O15303 3/20 0.49
GRIK2 Q13002 2/20 0.49
GRIK3 Q13003 2/20 0.49
GRM8 O00222 1/20 0.49
GRIN2D O15399 1/20 0.49
GRIN3B O60391 1/20 0.49
GSR P00390 1/20 0.49
GRM5 P41594 1/20 0.49
SLC1A3 P43003 1/20 0.49
SLC1A2 P43004 1/20 0.49
SLC1A1 P43005 1/20 0.49
GRIN1 Q05586 1/20 0.49
GRIN2A Q12879 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(R,S)-Ampa SCHEMBL19086372 1.00 GRIA1 (0.58) GRIA1GRIA3GRIA2GRIA4GRIK1
(R,S)-Ampa SCHEMBL68799 0.90 GRIA1 (0.69) GRIA1GRIA3GRIA2GRIA4GRIK1
(R,S)-Ampa SCHEMBL2458874 0.90 GRIA1 (0.69) GRIA1GRIA3GRIA2GRIA4GRIK1
(S)-Ampa SCHEMBL667915 0.90 GRIA1 (0.69) GRIA1GRIA3GRIA2GRIA4GRIK1
(R,S)-Ampa SCHEMBL7200262 0.89 GRIA1 (0.68) GRIA1GRIA3GRIA2GRIA4GRIK1
(R,S)-Ampa SCHEMBL7200264 0.89 GRIA1 (0.68) GRIA1GRIA3GRIA2GRIA4GRIK1
(R,S)-Ampa SCHEMBL6553747 0.87 GRIA1 (0.56) GRIA1GRIA3GRIA2GRIA4GRIK1
SCHEMBL3731488 0.81 GRIA1 (0.54) GRIA1GRIA3GRIA2GRIA4GRIK1
SCHEMBL12506417 0.81 GRIA1 (0.54) GRIA1GRIA3GRIA2GRIA4GRIK1
(S)-Ampa SCHEMBL28091565 0.80 GRIA1 (0.53) GRIA1GRIA3GRIA2GRIA4GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3580213-B1 AMPA RECEPTOR POTENTIATORS UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2024-03-27 EP disclosed
EP-3759092-B1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2023-12-20 EP disclosed
US-20230000847-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2023-01-05 US disclosed
CN-110520418-B AMPA receptor potentiators 加的夫大学学院咨询有限公司 2022-08-16 CN disclosed
US-11298345-B2 Compounds that modulates AMPA receptor function UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2022-04-12 US disclosed
CN-113891891-A Modulators of AMPA receptor signaling 戒毒及精神健康中心 2022-01-04 CN disclosed
US-11186567-B2 AMPA receptor potentiators UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2021-11-30 US disclosed
CN-107075485-B Corneal endothelial cell markers 国立大学法人大阪大学 2021-10-01 CN disclosed
US-20210139463-A1 AMPA RECEPTOR POTENTIATORS DRAIG THERAPEUTICS LTD (GB) 2021-05-13 US disclosed
US-20210113539-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION DRAIG THERAPEUTICS LTD (GB) 2021-04-22 US disclosed
CN-112004811-A Compounds that modulate AMPA receptor function 加的夫大学学院咨询有限公司 2020-11-27 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210139463-A1 AMPA RECEPTOR POTENTIATORS GRIN1, GRM1, GRM2 GRIA1 6/4885GRIA3 22/4885GRIA2 12/4885
US-20230000847-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A GRIA1 6/4885GRIA3 25/4885GRIA2 11/4885
US-20210113539-A1 COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION GRIN1, GRM1, GRIN2A GRIA1 6/4885GRIA3 25/4885GRIA2 11/4885
US-11298345-B2 Compounds that modulates AMPA receptor function GRIN1, GRM1, GRIN2A GRIA1 6/4885GRIA3 25/4885GRIA2 11/4885
US-11186567-B2 AMPA receptor potentiators GRIN1, GRM1, GRM2 GRIA1 6/4885GRIA3 22/4885GRIA2 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.