(R,S)-Ampa

(R,S)-Ampa

SCHEMBL2458874

Cc1onc(O)c1C[C@@H](N)C(=O)O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 5/20 0.69
GRIA3 P42263 5/20 0.69
GRIA2 P42262 4/20 0.61
GRIA4 P48058 4/20 0.61
MAPT P10636 2/20 0.50
GRIK1 P39086 2/20 0.50
GRIK5 Q16478 2/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
TSHR P16473 1/20 0.50
CYP2C19 P33261 1/20 0.50
KMT2A Q03164 1/20 0.50
GRIK2 Q13002 1/20 0.50
GRIK3 Q13003 1/20 0.50
GRIK4 Q16099 1/20 0.50
MAPK1 P28482 1/20 0.50
BLM P54132 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(R,S)-Ampa SCHEMBL68799 1.00 GRIA1 (0.69) GRIA1GRIA3GRIA2GRIA4MAPT
(S)-Ampa SCHEMBL667915 1.00 GRIA1 (0.69) GRIA1GRIA3GRIA2GRIA4MAPT
(R,S)-Ampa SCHEMBL7200264 0.98 GRIA1 (0.68) GRIA1GRIA3GRIA2GRIA4MAPT
(R,S)-Ampa SCHEMBL7200262 0.98 GRIA1 (0.68) GRIA1GRIA3GRIA2GRIA4MAPT
(R,S)-Ampa SCHEMBL23242452 0.90 GRIA1 (0.58) GRIA1GRIA3GRIA2GRIA4MAPT
(R,S)-Ampa SCHEMBL19086372 0.90 GRIA1 (0.58) GRIA1GRIA3GRIA2GRIA4MAPT
(R,S)-Ampa SCHEMBL6553747 0.88 GRIA1 (0.56) GRIA1GRIA3GRIA2GRIA4MAPT
(S)-Ampa SCHEMBL28091565 0.85 GRIA1 (0.53) GRIA1GRIA3GRIA2GRIA4MAPT
SCHEMBL8812980 0.85 GRIA1 (0.71) GRIA1GRIA3GRIA2GRIA4MAPT
SCHEMBL8812978 0.85 GRIA1 (0.71) GRIA1GRIA3GRIA2GRIA4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220142960-A1 Compositions and Methods for Treating Metabolic Disorders VEROSCIENCE LLC 2022-05-12 US claimed
EP-3311842-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS VeroScience LLC (US) 2018-04-25 EP claimed
US-20110244486-A1 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES PEREGO, CARLA (IT) 2011-10-06 US claimed
EP-2366106-A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES Perego, Carla (IT) 2011-09-21 EP claimed
WO-2010057647-A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES UNIVERSITA' DEGLI STUDI DI MILANO (IT) 2010-05-27 WO claimed
EP-4452918-A1 METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS) AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute (US) 2024-10-30 EP disclosed
WO-2023122276-A1 METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS (PAMS) AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute (US) 2023-06-29 WO disclosed
US-20220142960-A1 Compositions and Methods for Treating Metabolic Disorders VEROSCIENCE LLC 2022-05-12 US disclosed
EP-3966227-A1 COMPOSITIONS AND METHODS FOR THE VECTORED AUGMENTATION OF PROTEIN DESTRUCTION, EXPRESSION AND/OR REGULATION Voyager Therapeutics, Inc. (US) 2022-03-16 EP disclosed
US-20190160059-A1 Compositions and Methods for Treating Metabolic Disorders VEROSCIENCE LLC (US) 2019-05-30 US disclosed
EP-3311842-A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS VeroScience LLC (US) 2018-04-25 EP disclosed
US-20150011554-A1 Compositions and Methods for Treating Metabolic Disorders VEROSCIENCE LLC 2015-01-08 US disclosed
EP-0980358-A4 PHARMACOLOGICAL AGENTS LILLY CO ELI (US) 2001-02-07 EP disclosed
WO-2001007431-A2 BENZOTHIOPHENE DERIVATIVES ELI LILLY AND COMPANY (US) 2001-02-01 WO disclosed
US-6107499-A FACILITATING THE TRANSPORT OF A NEUROTRANSMITTER ACROSS THE BLOOD BRAIN BARRIER BY ADMINISTERING THE DRUG, A NEUROTRANSMITTER SUCH AS DOPAMINE COVALENTLY COUPLED TO A SINGLE, STRAIGHT-CHAINED FATTY ACID CARRIER MOLECULE NEUROMEDICA, INC. (US) 2000-08-22 US disclosed
EP-0980358-A1 PHARMACOLOGICAL AGENTS ELI LILLY AND COMPANY (US) 2000-02-23 EP disclosed
US-5994392-A PASSAGE OF DRUG THROUGH BLOOD BRAIN BARRIER NEUROMEDICA, INC. (US) 1999-11-30 US disclosed
WO-1998045270-A1 PHARMACOLOGICAL AGENTS ELI LILLY AND COMPANY (US) 1998-10-15 WO disclosed
US-5409710-A Foam cell drug delivery ENDOCON, INC. (US) 1995-04-25 US disclosed
WO-1994023706-A1 FOAM CELL DRUG DELIVERY ENDOCON, INC. (US) 1994-10-27 WO disclosed