Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.75 |
| ▸ | CTSC | P53634 | 9/20 | 0.71 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.55 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.54 |
| ▸ | BMX | P51813 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | ITK | Q08881 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.54 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.54 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.54 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23243735 | 0.88 | CTSC (0.72) | EGFRCTSC | |
| SCHEMBL23243684 | 0.87 | CTSC (0.72) | EGFRCTSC | |
| SCHEMBL23243738 | 0.87 | EGFR (0.78) | EGFRCTSCNUAK1NUAK2PLK4 | |
| SCHEMBL1706688 | 0.86 | EGFR (1.00) | EGFRCTSCNUAK1NUAK2PLK4 | |
| SCHEMBL23243746 | 0.85 | EGFR (0.60) | EGFRCTSC | |
| SCHEMBL23260249 | 0.83 | EGFR (0.58) | EGFRCTSC | |
| SCHEMBL23243741 | 0.83 | CTSC (1.00) | EGFRCTSCNUAK1NUAK2PLK4 | |
| SCHEMBL23243690 | 0.83 | CTSC (0.79) | EGFRCTSCNUAK1NUAK2PLK4 | |
| SCHEMBL23243737 | 0.83 | CTSC (0.85) | EGFRCTSCNUAK1NUAK2PLK4 | |
| SCHEMBL23243716 | 0.81 | CTSC (0.76) | EGFRCTSCNUAK1NUAK2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210114983-A1 | Cathepsin C inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-22 | — | — | US | disclosed |
| US-20210114983-A1 | Cathepsin C inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-04-22 | — | — | US | disclosed |
| CN-112601742-A | Cathepsin C inhibitors | 北京生命科学研究所 | 2021-04-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210114983-A1 | Cathepsin C inhibitors | CTSF, CTSE, CTSG | EGFR 12/4885CTSC 9/4885NUAK1 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.