Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 12/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.78 |
| ▸ | USP2 | O75604 | 9/20 | 0.78 |
| ▸ | RECQL | P46063 | 8/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.78 |
| ▸ | HPGD | P15428 | 8/20 | 0.78 |
| ▸ | MEN1 | O00255 | 7/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.78 |
| ▸ | THRB | P10828 | 6/20 | 0.78 |
| ▸ | MAPT | P10636 | 6/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | CASP1 | P29466 | 1/20 | 0.78 |
| ▸ | CASP7 | P55210 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.75 |
| ▸ | MC4R | P32245 | 1/20 | 0.75 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29487299 | 1.00 | TDP1 (0.78) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| Sulfosalicylic SCHEMBL29674900 | 0.89 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| SCHEMBL19555132 | 0.86 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| SCHEMBL26628251 | 0.86 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| SCHEMBL29537520 | 0.86 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| SCHEMBL30567156 | 0.86 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| SCHEMBL26597994 | 0.86 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| SCHEMBL12841672 | 0.85 | TDP1 (0.62) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| Hydrochloric Acid SCHEMBL29413670 | 0.85 | TDP1 (1.00) | TDP1KDM4EUSP2RECQLHSD17B10 | |
| SCHEMBL1650332 | 0.85 | TDP1 (0.62) | TDP1KDM4EUSP2RECQLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197767-A1 | COMBINATION OF ZIDOVUDINE WITH A TETRACYCLINE ANTIBIOTIC | HELPERBY THERAPEUTICS LIMITED (GB) | 2024-06-20 | — | — | US | disclosed |
| US-20230201235-A1 | INHIBITION OF NIDOVIRUSES THAT ENCODE NSP15 | THE UNIVERSITY OF CHICAGO (US) | 2023-06-29 | — | — | US | disclosed |
| CN-114765956-A | Combinations of zidovudine and tetracycline antibiotics | 赫尔普百治疗有限公司 | 2022-07-19 | — | — | CN | disclosed |
| WO-2021074598-A1 | COMBINATION OF ZIDOVUDINE WITH A TETRACYCLINE ANTIBIOTIC | HELPERBY THERAPEUTICS LIMITED (GB) | 2021-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230201235-A1 | INHIBITION OF NIDOVIRUSES THAT ENCODE NSP15 | TYMP, TYMS, ISG15 | TDP1 242/4885KDM4E 2895/4885USP2 1512/4885 |
| US-20240197767-A1 | COMBINATION OF ZIDOVUDINE WITH A TETRACYCLINE ANTIBIOTIC | TYMS, TYMP, DHFR | TDP1 2082/4885KDM4E 1512/4885USP2 3370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.