Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 14/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.62 |
| ▸ | MEN1 | O00255 | 9/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.62 |
| ▸ | USP2 | O75604 | 8/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.62 |
| ▸ | RECQL | P46063 | 7/20 | 0.62 |
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | THRB | P10828 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | CASP7 | P55210 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12841672 | 1.00 | TDP1 (0.62) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL3446 | 1.00 | TDP1 (0.62) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Sulfosalicylic SCHEMBL23359126 | 0.88 | TDP1 (0.81) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL4015 | 0.86 | TDP1 (0.73) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL23247761 | 0.85 | TDP1 (0.78) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL29487299 | 0.85 | TDP1 (0.78) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Hydrochloric Acid SCHEMBL20398184 | 0.84 | TDP1 (0.71) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Sulfosalicylic SCHEMBL29674900 | 0.77 | TDP1 (1.00) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Isoniazid SCHEMBL5791571 | 0.76 | TDP1 (0.61) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL23005369 | 0.73 | TDP1 (0.73) | TDP1KDM4EMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9463195-B2 | Dissolution of amyloid fibrils by flavonoids and other compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-11 | — | — | US | disclosed |
| US-9463195-B2 | Dissolution of amyloid fibrils by flavonoids and other compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-10-11 | — | — | US | disclosed |
| US-20140073611-A1 | METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM | NATIONAL TAIWAN UNIVERSITY (TW) | 2014-03-13 | — | — | US | disclosed |
| US-20140073611-A1 | METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM | NATIONAL TAIWAN UNIVERSITY (TW) | 2014-03-13 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| US-20100048510-A1 | DISSOLUTION OF AMYLOID FIBRILS BY FLAVONOIDS AND OTHER COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-25 | — | — | US | disclosed |
| US-20100048510-A1 | DISSOLUTION OF AMYLOID FIBRILS BY FLAVONOIDS AND OTHER COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073611-A1 | METHODS FOR DRUG SCREEN USING ZEBRAFISH MODEL AND THE COMPOUNDS SCREENED THEREFROM | PLOD3, MYOC, SLTM | TDP1 1111/4885KDM4E 2152/4885MEN1 4287/4885 |
| US-20100048510-A1 | DISSOLUTION OF AMYLOID FIBRILS BY FLAVONOIDS AND OTHER COMPOUNDS | B2M, APP, BACE2 | TDP1 2698/4885KDM4E 3921/4885MEN1 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.