Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 14/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.62 |
| ▸ | MEN1 | O00255 | 9/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.62 |
| ▸ | USP2 | O75604 | 8/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.62 |
| ▸ | RECQL | P46063 | 7/20 | 0.62 |
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | THRB | P10828 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | CASP7 | P55210 | 2/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650332 | 1.00 | TDP1 (0.62) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL3446 | 1.00 | TDP1 (0.62) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Sulfosalicylic SCHEMBL23359126 | 0.88 | TDP1 (0.81) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL4015 | 0.86 | TDP1 (0.73) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL23247761 | 0.85 | TDP1 (0.78) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL29487299 | 0.85 | TDP1 (0.78) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Hydrochloric Acid SCHEMBL20398184 | 0.84 | TDP1 (0.71) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Sulfosalicylic SCHEMBL29674900 | 0.77 | TDP1 (1.00) | TDP1KDM4EMEN1KMT2AUSP2 | |
| Isoniazid SCHEMBL5791571 | 0.76 | TDP1 (0.61) | TDP1KDM4EMEN1KMT2AUSP2 | |
| SCHEMBL23005369 | 0.73 | TDP1 (0.73) | TDP1KDM4EMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011031471-A2 | THE FUNGAL SREBP PATHWAY AS A TARGET FOR ANTI-FUNGAL AGENTS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-03-17 | — | — | WO | disclosed |