Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 9/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339179 | 0.80 | LOXL2 (0.44) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 | |
| SCHEMBL3129466 | 0.79 | CYP4F2 (0.42) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 | |
| SCHEMBL16594468 | 0.79 | NR2F2 (0.43) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 | |
| SCHEMBL8847552 | 0.78 | LMNA (0.36) | NR3C2TSHRGABRPGABRDGABRA1 | |
| SCHEMBL1419538 | 0.78 | CYP4F2 (0.44) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 | |
| SCHEMBL2328151 | 0.76 | RECQL (0.50) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 | |
| SCHEMBL20377228 | 0.76 | CYP4F2 (0.45) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 | |
| SCHEMBL2176535 | 0.76 | LOXL2 (0.56) | CYP4F2CYP4A11LOXL2ADORA3TSHR | |
| SCHEMBL30193091 | 0.76 | RECQL (0.50) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 | |
| SCHEMBL1388918 | 0.76 | GRM2 (0.46) | CYP4F2CYP4A11NR3C2LOXL2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356112-A1 | HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010054764-A1 | HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-05-20 | — | — | WO | disclosed |