Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23257624 | 1.00 | MAPT (0.43) | MAPTL3MBTL1KDM4EALDH1A1TDP1 | |
| SCHEMBL27310728 | 1.00 | MAPT (0.43) | MAPTL3MBTL1KDM4EALDH1A1TDP1 | |
| SCHEMBL29813990 | 1.00 | MAPT (0.43) | MAPTL3MBTL1KDM4EALDH1A1TDP1 | |
| SCHEMBL29813941 | 1.00 | MAPT (0.43) | MAPTL3MBTL1KDM4EALDH1A1TDP1 | |
| SCHEMBL20564754 | 0.88 | KDM4E (0.44) | KDM4EALDH1A1TDP1 | |
| SCHEMBL29176910 | 0.77 | NLRP3 (0.46) | KDM4E | |
| SCHEMBL23257333 | 0.75 | KDM4E (0.39) | KDM4EALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL914510 | 0.74 | MAPT (0.67) | MAPTL3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL106076 | 0.74 | MAPT (0.67) | MAPTL3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL106075 | 0.74 | MAPT (0.67) | MAPTL3MBTL1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3628045-B1 | COMPOUNDS | UNIV SHEFFIELD (GB) | 2024-07-03 | — | — | EP | disclosed |
| US-20210113534-A1 | COMPOUNDS | THE UNIVERSITY OF SHEFFIELD (GB) | 2021-04-22 | — | — | US | disclosed |
| CN-110891951-A | Compound (I) | 谢菲尔德大学 | 2020-03-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210113534-A1 | COMPOUNDS | MRGPRX2, MC2R, ADM2 | MAPT 3763/4885L3MBTL1 3736/4885KDM4E 4843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.