Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | DBH | P09172 | 2/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 7/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23250771 | 0.76 | HTR2C (0.42) | HTR2CPDK2PDK4HTR6NOTUM | |
| SCHEMBL930210 | 0.76 | HTR2C (0.48) | HTR2CPDK2PDK4NOTUMHDAC4 | |
| SCHEMBL21471571 | 0.73 | DBH (0.45) | DBHHDAC4HDAC2HDAC8 | |
| SCHEMBL2048750 | 0.73 | NOTUM (0.38) | HTR2CPDK2PDK4NOTUM | |
| SCHEMBL2045827 | 0.72 | HTR2C (0.48) | HTR2CPDK2PDK4HTR6NOTUM | |
| SCHEMBL930208 | 0.72 | ALDH1A1 (0.54) | HTR2CPDK2PDK4NOTUM | |
| SCHEMBL21471570 | 0.72 | PTGDR2 (0.45) | DBHHDAC4HDAC2HDAC8 | |
| SCHEMBL16956125 | 0.71 | HTR2C (0.74) | HTR2CPDK2PDK4HTR6 | |
| SCHEMBL27857366 | 0.71 | ALDH1A1 (0.52) | HTR2CPDK2PDK4NOTUM | |
| SCHEMBL4969775 | 0.70 | NOTUM (0.49) | HTR2CNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073131-A2 | METHOD OF TREATING NEURODEGENERATIVE DISEASES | THE BOARD OF TRUSTEES OF THE UNIVESITY OF ILLINOIS (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2021076938-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2021-04-22 | — | — | WO | disclosed |