Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 6/20 | 0.65 |
| ▸ | FLT3 | P36888 | 4/20 | 0.65 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | OGT | O15294 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6953018 | 0.81 | FLT3 (0.77) | MIFFLT3GRM5GSK3BNOTUM | |
| SCHEMBL28464554 | 0.79 | FLT3 (0.73) | MIFFLT3GRM5GSK3BOGT | |
| SCHEMBL1674373 | 0.79 | FLT3 (0.73) | MIFFLT3GRM5GSK3BKDM4E | |
| SCHEMBL17980671 | 0.79 | MIF (1.00) | MIFFLT3GRM5GSK3BNPC1 | |
| SCHEMBL29158520 | 0.79 | FLT3 (1.00) | MIFFLT3GRM5GSK3BNOTUM | |
| SCHEMBL5202573 | 0.78 | FLT3 (0.72) | MIFFLT3GRM5GSK3BNOTUM | |
| SCHEMBL2192371 | 0.78 | FLT3 (0.72) | MIFFLT3GRM5GSK3BMETAP1 | |
| SCHEMBL19386218 | 0.78 | FLT3 (0.63) | MIFFLT3GRM5GSK3BKDM4E | |
| SCHEMBL5203644 | 0.78 | FLT3 (0.76) | MIFFLT3GRM5GSK3B | |
| SCHEMBL31373412 | 0.76 | FLT3 (0.66) | MIFFLT3GRM5GSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230172911-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-08 | — | — | US | disclosed |
| US-20230172911-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-06-08 | — | — | US | disclosed |
| US-20210113533-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210113533-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | RRM2, RRM2B, RRM1 | MIF 1922/4885FLT3 3009/4885GRM5 1859/4885 |
| US-20230172911-A1 | METHOD OF MODULATING RIBONUCLEOTIDE REDUCTASE | RRM2, RRM2B, RRM1 | MIF 1922/4885FLT3 3009/4885GRM5 1859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.